I've been on a moderately low dose of Zoloft for years, never really kicked the depression completely. Recently, I worked with client who was flat on her face with depression, eating disorders, bedridden -- who went to see an integrative psychiatrist who weaned her off her meds and put her on SAM-E and a bunch of other supplements -- OMG -- she's like a new person -- and within only a few weeks.
I've now started supplementing with 5-HTP and am very having good results. Am now trying DPL and will keep y'all posted. Here is a link to the shrink -- she's expensive, but you may not have to actually go to her -- I didn't, just read her material. If you read the info from the link below, you will get ALOT of very good, very supportive info. Hope it helps somebody. And Down With Big Pharma!
http://cassmd.com/pdfs_folder/ReclaimYourBrain2.pdf